安慰劑效應增強了？被低估了？還是新藥療效低了？
最近在《連線》看了報導"Placebos Are Getting More Effective. Drugmakers Are Desperate to Know Why"，內文指製藥巨頭默克公司最近在測試新的抗抑鬱藥物MK- 869時便遭遇到嚴重的失敗，此藥在初期測試中表現甚佳，副作用甚少，可是在進一步測試時卻出現安慰劑療效超過新藥的結果，最終默克公司決定放棄原初被看好能為公司帶來極大利潤的新藥MK-869了。
其實很多藥廠發現他們生產的藥物，特別是與精神科相關的類別，自80年代始就越來越不能通過安慰劑測試，藥物的效能在大多數測試中都無法超過安慰劑，自2001-2006年，第二階測試因新藥療效無法超越安慰劑而要放棄的上升至20%，第二階段則上升到11%。2007年美國FDA只批准19種新藥推出，是自83年來最少的，2008年也只有24種。
有學者提議藥廠與學術組織合作成立數據分享資料庫，讓研究人員有足夠的資料分析問題所在，可是這涉及商業秘密而不為藥廠所採納，藥廠目前只個別僱用對此問題有深入認識的研究人員幫助設計出更佳的實驗以擺脫安慰劑效應與真實藥效糾纏不清的弊病。
我覺得這篇文章最令人印像深刻及重要的地方為：
1. 指出二次大戰時因有一名醫師Henry Beecher看見有護士用假止痛劑注射也能為病人止痛的事件，才發現有安慰劑效應的事實，並在1962年 thalidomide這種安眠藥導至新生嬰兒雙手殘廢的事件後，人們驚覺要有更安全及更精確測試的方法來驗證藥物的可用性，於是關於安慰劑及雙盲測試等理論就大行其道(順勢療法專家則稱此法早在20世紀初由他們引進，只是當時沒有有受到應有的重視)，成為藥廠及監管機構測試藥效的黃金定律。
可是這條理論又帶來其他更大的困擾，Beecher除了被批評把安慰劑效應理論用錯誤地用在治療流行性感冒的藥物上，人們在大部份情況下都能自然痊癒，另外Beecher還低估了能引發安慰劑效應因素的數量及其真實的威力，使其測試方法出現了嚴重缺憾而常出現失效的問題。
2.關於安慰劑的真正威力，研究員Benedetti發現安慰劑效應並不是限於止痛(因腦部分泌類似嗎啡的物質)，其還能引起的反應包括調節心跳與呼吸、改善帕金森患者的活動能力、改善情緒、強化認知能力，減輕消化功能紊亂的症狀、緩解失眠、限制與壓力相關荷爾蒙如腎上線素、胰島素的分泌，可以說安慰劑效應啟動了人體的自我自癒的機制，幾乎把整個身體機能都進行了優化。
另一位研究員Ted Kaptchuk則發現安慰劑在對腸易激綜合症不單比得上那些被認為真實有效的藥物，其有效期更長達一個星期之久，遠超以前人們對安慰劑有效期的預算。安慰劑並不只是止痛劑，而是有真實的療效，與真藥一樣可有助病人回覆健康，當然與之相反的自然是負安慰劑效應了，其對病人的健康也自然是有負的的影響了。
3.關於能引發安慰劑效應的因素，研究員William Potter發現地理因素會對藥物的效力產生影響，一種藥物在此地能發揮高於安慰劑的療效，但到另一地則不行；另外不同的測試人員對測試同一種藥很多時都得出相反不同的結果，不管實驗設計得如何嚴謹也好。
其實安慰效應與人們對「藥物」的預設與期望是有極大的關係，病人對「藥物」的看法越正面，安慰效應便越強，一些疾病如老年痴呆症破壞了病人的腦部，包括記憶新事物與及對這些事物產生「預設」的能力，在這類病人身止痛劑藥效單獨運行，缺少了安慰劑效應的幫助，所以連止痛的效力也下降了。
能影響人們預設與期望的因素甚多，例如「藥物」的顏色、份量、品牌、藥名意義；醫師對病人的說話、藥廠的廣告宣傳、病人過往經驗、地區文化等，可以說能啟動安慰劑效應的因素幾乎無孔不入，難以完全避免。
這些問題使藥廠越來越找到合適的測試者(心中已有預質設立場)，一些地區如非洲、印度、中國及前蘇聯，民眾希望得基本的醫療服務，藥廠除了在一些極易受安慰劑效應影響的疾病(如精神病)及在這些症中找較輕症者做實驗外，其提供測試者的醫療照料質素竟比在美國病人能實際接受的待遇還要好，近乎奢華，在「更好及及專業的照料」(認為更高的療效)的心態影響下，安慰效應自然也大增了。
4.現行使用的雙盲測試方法對於排除安慰劑效應，特別是精神科類藥物，都不是太可靠的，發明於近50年前用作診斷嚴重抑鬱症(要往精神病院)的 HAM-D問卷，現在很多專家都質疑當時以此法定義出來的抑鬱症是不是與今日藥廠所謂的抑鬱症等同，一些如社交恐懼症、經前憂鬱症等在90年代(亦是安慰劑效應問題逐步浮現的年代)「發現」的慢性精神性疾病在定義上過於迷糊，在神經學的領域上仍有很大的爭議，其他如慢性痛症、性功能障礙、帕金森症等疾病亦遇上類似的問題，藥廠要找到新的方法解決安慰劑效應的問題(目前看來藥廠對這方面還很有自信)，否則很難有效用藥治療這類病人。
其他相關的說法：
我記得《藥廠黑幕》一書曾提到有關新藥不如舊藥的問題(P142-144)，正好與報導所描述的情況相呼應，藥廠對6種廣為使用的抗憂鬱藥所進行的臨床實驗大多數隻有6個星期，而且由於制度的問題，藥廠不必公佈所有的實驗測試結果，只需公佈二項臨床實驗，而藥效只需比安慰劑優勝一點點就行，因此即使10次測試中有8次不能達標，把2次成功的拿作證據即可，即使藥效差距只相差兩成(在臨床上表現相差不遠)仍無關重要，結果在藥廠隱惡揚善的廣告宣傳下，人們便被誤導以為藥物有很高的療效，在一些情況下藥物更會帶來傷害健康的副作用，如用作治療更年期症狀及預防心臟病的動情激素與黃體激素合用的荷爾蒙替代療法被其他研究指反增加心臟病發的機會，因此即使並不是每一種西藥也是如此，我們仍需要對這個普遍的現像提高警覺。
另一本書《發明疾病的人》則更指出不少這類的所謂精神病是藥廠為求利潤而強加在病人身上的(P29-32)，並用廣告宣傳說服這些人相信自己患了那些所謂的病，一定要非吃藥不可，不少所謂的精神病其實根本不能算是病或有其他更好的非藥物治療可以應對。
「希希症」(Sisi-Syndrom)：「發現」於1998年，病徵為內心有憂鬱傾向，但在人們面前通常表現得活力充沛，對生命十足肯定，以掩飾自己的病態沮喪，並指3百萬德國人患有此症，直到2003年才被人揭發造假。
「籠中虎症候群」：一向對小孩很好的父親情緒因不明原因轉壞，再也無法好好做判斷，還會不停怨東怨西，就像一頭關在籠裡的老虎，每5個父親就有人患上此症。
「天堂憂鬱症」：退休後老人在陽光普照、優美得猶如天堂的環境下出現憂鬱症狀。
「悠閒病」：在悠閒、往度假勝地時發病，病徵包括疲勞、頭痛、四肢疼痛、嘔吐與憂鬱，3%的人會患上此症，使患者對悠閒無福消受。
「全身性開朗症」：出現活潑好動、無憂無慮與不切實際的症狀。
「懼血懼醫症」：症狀包括害怕醫生(被認為因害怕見血？)、拒絕就醫，2-3%的德國人患上此症。
以上的例子也提供了有關所謂安慰劑效力越來越強問題的解釋，很可能那些所謂的精神病重來都不應用藥物進行治療，從心啟動的安慰劑效應似乎是更重要的。
補充新聞：
情緒消沉或增加癌症死亡率
http://big5.xinhuanet.com/gate/big5/news.xinhuanet.com/world/2009-09/16/content_12059246.htm
加拿大不列顛哥倫比亞大學研究人員發現，情緒消沉或可增加癌症患者死亡率。但科學家稱情緒消沉癌症患者不應為此驚慌，因為瞭解二者關係有待更多研究。
死亡率增加
科學家發現，情緒消沉或有抑鬱症的癌症患者死亡率比精神狀況良好的癌症患者死亡率高。
在針對９４１７名癌症患者的２６項獨立研究中，有抑鬱症徵兆的癌症患者死亡率比精神狀況良好患者死亡率高２５％；確診抑鬱症的癌症患者死亡率比精神狀況良好患者死亡率高３９％。
研究人員在動物實驗中發現，壓力對腫瘤生長及癌細胞擴散均有影響。這表明消沉情緒或許會影響到人體激素水準和免疫系統，另外，消極情緒使癌症病人不願配合治療可能也是他們死亡率增高原因之一。
「我認為人們應該認真對待情緒消沉，」研究負責人吉莉安·薩坦對美聯社記者說，「希望這一研究結果能促使人們在傳統癌症治療中加入心理社會治療。」
相關研究報告１４日發表在美國《癌症》雜誌上。
原文： http://richardfx.blogspot.com/2009/09/blog-post_15.html
7.3.10
22.9.09
Getting beyond Bitterness
Couples who survive the break-in period continue to go through cycles of closeness and distance. Some conflicts are resolved, others are avoided, for a few keep cropping up from time to time. Arguments still occur, but the nature of these heated discussions should change over time. They become less bitter and less violent. There is less blaming and a greater feeling that both of you are in the same boat. if arguments don't become less frequent, less intense, and shorter, partners would do well to see what they are doing to keep emotionally high and listening absent.
Successful couples learn that the methods most commonly used in attempting to induce unilateral change - complaining, cajoling, sweet talking, nagging, inducing guilt, becoming angry, and using other forms of emotional manipulation - don't work very well. When empathy doesn't come easy, successful partners work at it - making themselves listen even when they would prefer to be heard. (You don't have to feel sympathetic to listen. Sometimes showing concern works from the outside in, the way smiling can put you in a good mood.)
Problems arise when patterns keep too many secrets, say yes when they don't mean it, or don't tell the truth about their feelings because they're afraid of arguments. The broken promises that result from being afraid to say no are too great a price to pay for avoiding honest argument. Learning to say no enables you to say yes and mean it. If you're wishing that your partner would realize this, ask yourself, why would someone lie to you?
Trust allows partners to relax vigilance. Being honest is central to establishing this trust, as is being open, listening to and acknowledging the hard things your partners says. Love that grows out of and feeds into self-respect is love for ourselves as we are, not for a partial and carefully selected portion. The person who hesitates to speak wonders if it's safe to broach certain embarrassing or controversial issues. The person who never opens up to you has already decided that it isn't safe to speak.
If we want the truth from our partners, we must make it safe for them to tell it.
Unfortunately, even with the best of intentions, many couples reach a point where they get bogged down in bitterness and can't hear each other at all. Pursuers get sick of pursuing and distancers get tired of all the pressure, until one or both of them pulls back so far that they reach what family therapist Phil Guerin calls an "island of invulnerability." Anger and animosity build to bitter resentment, and two people who once thrilled each other now give up on each other. Giving up on satisfaction in favor of security, retreating to the island of invulnerability, is cold comfort. But even loneliness sometimes feels better than constant conflict.
Mates bogged down in bitterness can take a step toward releasing themselves from ice castles of frozen hope by taking a hand look at those hopes. If you're willing to let go of blaming and look for a way back together, examine your expectations. Are your conflicts based on a desire for a partner who is fundamentally different from the one you married? if you're chronically irritated with your partner for being who she or he is, rather than about some particular behavior, then you are in the wrong relationship and it's never going to be very fulfilling. The only things worth fighting about the things that can be changed.
People come to intimate partnership with an interesting and self-contradictory pair of expectations. they expect their partners both to duplicate the good aspects of their own families and to make up for the bad. To make matters worse, these expectations are often directed toward a partner's limitations rather than his or her strengths.
Don't judge your partner by measuring him (or her) against your strengths, measure him by his strengths. Everybody wants to be appreciated for their contributions.
No one benefits when weaknesses or shortcoming becoming the principal focus of attention in a relationship."
.........
~The Lost Art of Listening ~ Michael P. Nichols
Mates bogged down in bitterness can take a step toward releasing themselves from ice castles of frozen hope by taking a hand look at those hopes. If you're willing to let go of blaming and look for a way back together, examine your expectations. Are your conflicts based on a desire for a partner who is fundamentally different from the one you married? if you're chronically irritated with your partner for being who she or he is, rather than about some particular behavior, then you are in the wrong relationship and it's never going to be very fulfilling. The only things worth fighting about the things that can be changed.
People come to intimate partnership with an interesting and self-contradictory pair of expectations. they expect their partners both to duplicate the good aspects of their own families and to make up for the bad. To make matters worse, these expectations are often directed toward a partner's limitations rather than his or her strengths.
Don't judge your partner by measuring him (or her) against your strengths, measure him by his strengths. Everybody wants to be appreciated for their contributions.
No one benefits when weaknesses or shortcoming becoming the principal focus of attention in a relationship."
.........
~The Lost Art of Listening ~ Michael P. Nichols
20.8.09
28.6.09
12.2.09
31.1.09
11.1.09
4.1.09
Photographs of 2008
The hand of a dead body lies on the ground amongst the rubble of the earthquake ravaged town May 15, 2008 in Beichuan, Sichuan province, China. (Paula Bronstein/Getty Images) #
A rescue helicopter prepares to hoist aboard surviving Japanese climber Hideaki Nara near the summit of Aoraki Mount Cook in New Zealand on December 5, 2008. A Japanese climber stranded for six days just below the summit had died just hours before rescuers reached him and a compatriot, local media reported. The two Japanese climbers were forced to huddle in a tent 50 meters below the 3,754-meter (12,349 feet) peak, as poor weather and high winds foiled attempts to rescue the men by helicopter. (REUTERS/The Christchurch Press/John Kirk-Anderson) #
In this Jan. 11, 2008 photo, eagles await transfer to a warm U.S. Fish and Wildlife warehouse after being rescued from the cold in Kodiak, Alaska. They were among 50 eagles which dove into the back of an uncovered dump truck full of fish guts and became too wet to fly away. (AP Photo/Jay Barrett) #
Lightning bolts appear above and around the Chaiten volcano as seen from Chana, some 30 kms (19 miles) north of the volcano, as it began its first eruption in thousands of years, in southern Chile May 2, 2008. Cases of electrical storms breaking out directly above erupting volcanoes are well documented, although scientists differ on what causes them. Picture taken May 2, 2008. (Carlos Gutierrez)
Democratic presidential candidate Sen. Barack Obama waves to the crowd at a rally in the rain at the University of Mary Washington in Fredericksburg, Va. Saturday, Sept. 27, 2008. (AP Photo/Alex Brandon) 
Samuel Peter from Nigeria receives a punch from Vitali Klitschko of Ukraine during their WBC heavyweight boxing world championship fight in Berlin, Germany on Oct. 11, 2008. Klitschko won the fight after round nine due to technical knock out. (AP Photo/Herbert Knosowski) #
A solar eclipse can be seen above the Jiayuguan Fort on the Great Wall of China in the town of Jiayuguan, Gansu Province, China on August 1, 2008. (REUTERS/David Gray) #
Drummers perform during the Opening Ceremony for the 2008 Beijing Summer Olympics at the National Stadium on August 8, 2008 in Beijing. (Adam Pretty/Getty Images) #
27.12.08
25.12.08
6.11.08
Am I suffering from Pre-Dementia or.....
I think I had deleted the XP accidentally, as I can open the Linux only. The files under XP were all gone! How come???
Other than the poorer memory, I have confusion, inattention and trouble putting thoughts into words. So...oh... come on....
Pre-Dementia, one form of which is sometimes called MCI, or Mild Cognitive Impairment, refers to decline in cognitive ability amongst younger adults that may become Alzheimer's.
Breathtakingly, up to 1 million people every year in the U.S. are new sufferers of pre-Dementia, not including the 500,000 people per annum who are diagnosed with Alzheimer's by a physician.
"We're seeing that in fact there's a much larger burgeoning problem out there" of people at risk of developing dementia, said Dr. Ronald Petersen, the Mayo scientist who led the study.
Dr. Ralph Nixon, a New York University psychiatrist and scientific adviser to the Alzheimer's Association, was blunt.
"We're facing a crisis," he said.
There are no treatments now to prevent this mental slide or reverse it once it starts.
But that may be changing. Researchers on Monday reported early, somewhat encouraging results from an experimental nose spray that seemed to improve certain memory measures in a study of mildly impaired people.
The drug, for now just called AL-108, needs testing in a longer, larger study. It is being developed by Allon Therapeutics Inc., based in Vancouver, B.C.
Doctors said it shows the potential for new types of medicines that target the protein tangles that kill nerve cells, instead of targeting the sticky brain deposits that have gotten most of the attention up to now.
The studies were reported at the International Conference on Alzheimer's Disease in Chicago.
Petersen is the scientist who defined mild cognitive impairment, or MCI, as a transition phase between healthy aging and dementia. It is more than "senior moments" like forgetting where you parked the car, but not as severe as having dementia, where you forget what a car is for.
People with it have impaired memory but not other problems like confusion, inattention or trouble putting thoughts into words.
The Alzheimer's Association says more than 5 million Americans have Alzheimer's, but no estimate for this "pre-dementia" has been available until now.
Petersen's federally funded study involved roughly 1,600 people, ages 70 through 89, living in Olmstead County, which surrounds the Mayo Clinic in Rochester, Minn. All tested normal when they were enrolled in the study, but more than 5 percent had developed mild impairment when evaluated a year later.
Men were nearly twice as likely as women to develop it. That's a surprise, because some studies have found more women with Alzheimer's than men. But there may be a simple explanation:
Even though more men may be impaired, women outlive them and therefore have more time to develop full-blown dementia.
"This is a very large and important issue for our country and for the world," said Duke University psychologist Brenda Plassman. A smaller study she published earlier this year backs up the Mayo study's findings.
The mild impairment rate is two to three times larger than many researchers had expected, Petersen said.
"It's the iceberg under the tip," agreed Dr. R. Scott Turner, incoming director of the memory disorders program at Georgetown University Medical Center. A prime goal is finding drugs to treat the mild impairment before Alzheimer's develops.
Other than the poorer memory, I have confusion, inattention and trouble putting thoughts into words. So...oh... come on....
U.S. in Crisis: Do a Million Men March towards Cognitive Impairment each Year?
Mayo Clinic Scientist Dr. Ron Peterson presented data at the International Alzheimer's Conference in Chicago that shows an astounding increase, particularly in men, in what was presented to the world media as Pre-Dementia.Pre-Dementia, one form of which is sometimes called MCI, or Mild Cognitive Impairment, refers to decline in cognitive ability amongst younger adults that may become Alzheimer's.
Breathtakingly, up to 1 million people every year in the U.S. are new sufferers of pre-Dementia, not including the 500,000 people per annum who are diagnosed with Alzheimer's by a physician.
"We're seeing that in fact there's a much larger burgeoning problem out there" of people at risk of developing dementia, said Dr. Ronald Petersen, the Mayo scientist who led the study.
Dr. Ralph Nixon, a New York University psychiatrist and scientific adviser to the Alzheimer's Association, was blunt.
"We're facing a crisis," he said.
There are no treatments now to prevent this mental slide or reverse it once it starts.
But that may be changing. Researchers on Monday reported early, somewhat encouraging results from an experimental nose spray that seemed to improve certain memory measures in a study of mildly impaired people.
The drug, for now just called AL-108, needs testing in a longer, larger study. It is being developed by Allon Therapeutics Inc., based in Vancouver, B.C.
Doctors said it shows the potential for new types of medicines that target the protein tangles that kill nerve cells, instead of targeting the sticky brain deposits that have gotten most of the attention up to now.
The studies were reported at the International Conference on Alzheimer's Disease in Chicago.
Petersen is the scientist who defined mild cognitive impairment, or MCI, as a transition phase between healthy aging and dementia. It is more than "senior moments" like forgetting where you parked the car, but not as severe as having dementia, where you forget what a car is for.
People with it have impaired memory but not other problems like confusion, inattention or trouble putting thoughts into words.
The Alzheimer's Association says more than 5 million Americans have Alzheimer's, but no estimate for this "pre-dementia" has been available until now.
Petersen's federally funded study involved roughly 1,600 people, ages 70 through 89, living in Olmstead County, which surrounds the Mayo Clinic in Rochester, Minn. All tested normal when they were enrolled in the study, but more than 5 percent had developed mild impairment when evaluated a year later.
Men were nearly twice as likely as women to develop it. That's a surprise, because some studies have found more women with Alzheimer's than men. But there may be a simple explanation:
Even though more men may be impaired, women outlive them and therefore have more time to develop full-blown dementia.
"This is a very large and important issue for our country and for the world," said Duke University psychologist Brenda Plassman. A smaller study she published earlier this year backs up the Mayo study's findings.
The mild impairment rate is two to three times larger than many researchers had expected, Petersen said.
"It's the iceberg under the tip," agreed Dr. R. Scott Turner, incoming director of the memory disorders program at Georgetown University Medical Center. A prime goal is finding drugs to treat the mild impairment before Alzheimer's develops.
7.10.08
機情
今天和弟弟談起相機和鏡頭，由攝影到自資生意，「打雀」到「打仔」，童年回憶到中年危機，無所不談。苦惱的日子裏，誠樂事也。
說來我還是菲林死舊派，尤愛機械單反此志不渝，FM 2 是可托終身沒錯 ; 我曾追求過 F 3，但初戀才是最愛最難忘; D70s 只是方便，沒感覺可言，想這不是愛情，是無情; GD-R 更如陌路人，討厭他的冷峻精確，全不對調， 想當初的「二世組發花癲花錢妄想症」，也為自己病態難堪。
為何說起這些呢? 當然是近期推出的 D700 所致，我只對 full frame 有興趣，可兩萬多塊太貴了，D3 又更貴更重。而且，數碼相機是忘情的追索，荷包是無情的乾涸，我心已累得可以，非不為矣，不能也。(其實我又開始病發，只是對象是Nikon AF-S 14-24mm f/2.8G ED而已)。
斷腸人在天涯...
說來我還是菲林死舊派，尤愛機械單反此志不渝，FM 2 是可托終身沒錯 ; 我曾追求過 F 3，但初戀才是最愛最難忘; D70s 只是方便，沒感覺可言，想這不是愛情，是無情; GD-R 更如陌路人，討厭他的冷峻精確，全不對調， 想當初的「二世組發花癲花錢妄想症」，也為自己病態難堪。
為何說起這些呢? 當然是近期推出的 D700 所致，我只對 full frame 有興趣，可兩萬多塊太貴了，D3 又更貴更重。而且，數碼相機是忘情的追索，荷包是無情的乾涸，我心已累得可以，非不為矣，不能也。(其實我又開始病發，只是對象是Nikon AF-S 14-24mm f/2.8G ED而已)。
斷腸人在天涯...攝影於我是感覺多於技術，最好的相機，是自己最喜愛最熟識的那一部，機一上手，感覺良好滿足經已完滿。我手「照」我心，是近年體驗...
8.4.08
Interesting question by Bateson
"A certain mother habitually rewards her small son with ice-cream after he eats his spinach. What additional information would you need to be able to predict whether the child will:a. Come to love or hate spinach,
b. Love or hate ice-cream,
c. Love or hate Mother?"
I'd spent one day to figure out what he
7.3.08
轉: 對不起，我還是在逃避
對不起，我還是在逃避
我的生命，從沒有乎合過燦爛的預期
對不起，又一次走到絕地
對不起，再一次辜負你
有時我會想，若果我也去看看面相
那搖著羽扇的先生，究竟會怎樣想
事業前途愛情健康，會否依然反覆無常？
也許他會深深的為我歎息，歎息比他額上的皺紋還長
從來都沒有放棄，為何在最後都選擇了逃避？
明明堅信不要靠運氣，但惡運來時為何就心死？
當我看到你，有時想你也許會像珍珠般優美
但對不起，現在的你還要像鮮花栽在沙漠旱地
友人說，自憐是最可悲的賣相
我也明白，做人不能依靠別人的堅強
對不起，我還不明白生命的方向
哀傷，哀傷，雖有翅膀卻無處飛翔
我的生命，從沒有乎合過燦爛的預期
對不起，又一次走到絕地
對不起，再一次辜負你
有時我會想，若果我也去看看面相
那搖著羽扇的先生，究竟會怎樣想
事業前途愛情健康，會否依然反覆無常？
也許他會深深的為我歎息，歎息比他額上的皺紋還長
從來都沒有放棄，為何在最後都選擇了逃避？
明明堅信不要靠運氣，但惡運來時為何就心死？
當我看到你，有時想你也許會像珍珠般優美
但對不起，現在的你還要像鮮花栽在沙漠旱地
友人說，自憐是最可悲的賣相
我也明白，做人不能依靠別人的堅強
對不起，我還不明白生命的方向
哀傷，哀傷，雖有翅膀卻無處飛翔
6.3.08
錯綜複雜...
寫緊個 case report, 感覺像極言情小說...
比史內卜對莉莉的愛情... 理直氣壯和理所當然，有前無後、打死罷就的勇往直前，計無遺漏但冷暖自知的孤獨...
我對別的沒意見，只對史內卜的有意見!!! (日內或會發表，但現還是繼續我的 "言情小說"吧...)
比史內卜對莉莉的愛情... 理直氣壯和理所當然，有前無後、打死罷就的勇往直前，計無遺漏但冷暖自知的孤獨...
我對別的沒意見，只對史內卜的有意見!!! (日內或會發表，但現還是繼續我的 "言情小說"吧...)
16.12.07
閱讀紀錄
閱讀紀錄
在今年你已讀完 74 本書 ， 總數為 22251 頁| 年份 | 書籍量 | 總頁數 |
|---|---|---|
| 2007 | 74 | 22251 |
| 2006 | 40 | 10585 |
| 2005 | 40 | 9133 |
哈.... 當然主要都是無聊小說之類....
11.12.07
《樓下的房客》
凌晨四點，剛把這書看完，心情難受到不敢入睡，害怕惡夢.. ..嘔心程度比「所多瑪 120天」更甚，恐怖從來不是血腥變態，反是人們互動間的不可料. ..
很後悔讀這書，更懊惱選擇「明天見 case」前的深宵時讀。絕不推薦這書，縱然言之有物，佈局舖排順 暢，故事性強，一開始讀便捨不得放下....
總之害我至今還有餘悸，故給一粒星 (應該有三粒...)
3.12.07
《誅仙 》
中國式魔幻武俠 : 主角和燒火棒，活像摩考克筆下的白子英雄和寶劍，吸噬人血獲得力量。學道青云門如入讀魔法學校、道術法器如咒語魔杖、七脈會武更有《火盃的考驗》魔法學生互相鬥法比較的感覺。有搞笑的場面和語句，有少年情竇初開的鬱郁和忽冷忽熱的難受，更
比《崑崙》精彩。
全書共 8 集，暫時認為小說可分為 2 部份，上半由第 1 至 4.5 集，主題是「愛情」，由張小凡和碧瑤起，獸神和玲瓏作結。接著筆鋒一轉，一場正道和妖魔大戰牽起書中最高潮，繼而殘存喘息，拖拖拉拉延至第六集，還未見起色...
不過前半也的確精彩萬分、哀怨纏綿，明明叫人興奮，隱隱又叫人心痛。得知任賢齊飾演張小凡... 唉... 從來小說拍劇，都是件既期望又失望的事情。
第七集: 讀到田不易在義莊和鬼厲說完兩句話後，想不到自己真的哭了。只是他們師徒倆的感情，我有保留。田不易不是不大過問這老七的事嗎? 也不見他親自教導他，張的青云武功由大師兄教，第三層是師姊偷偷給他祕笈自己練。如果張小凡不是脫穎而出，不是給迫反; 若張還是老老實實在大竹峰燒飯，田會繼續看他不爽，給他面色看。反之，田不易喚他一句:「老七」，什麼冤屈苦楚，都像寒雪被冬日一下子溶掉，張小凡不再孤獨地面對整個世界。
唉... 結局虎頭蛇尾 ! 失望 !
我是誅仙中的誰呢?
- 天賦過人,兄弟情深的林惊羽：46.53%
- 純真無暇,冰雪聰明的小環：16.85%
- 道貌岸然,心懷不軌的雲易嵐：13.96%
- 嬌媚萬千,暗藏心機的金瓶兒：9.30%
- 大義滅親,爲義捨身的玲瓏：7.08%
- 嬌豔無比,嫵媚萬分的小白：6.12%
- 諱莫如深,神秘莫測的鬼先生：0.17%
28.11.07
相睇...識
一眾學生正聚精會神，一位同學正口若懸河...
「...佢結左婚，係相睇識0既，老婆同女住廣州，而家個女 7 歲大....」
Supervisor 趨前，神色頗凝重地問: 「咁...佢地行唔行到房 ?」
同學微頓，「得... 個女都 7 歲...」語帶少許猶豫，但很快便接上。
「你知喇，有兩個器官架嘛，你知佢用邊個...」Supervisor 追問那同學...
一眾動作靜止，連眼睛也沒轉，Supervisor 立時察覺有異。
「雙體式喎，你講話係雙體式.........哦..... 你話佢地係相睇果陣識。我以為你.....」
大家穴道突然被解開，陷入一陣爆笑.....
「...佢結左婚，係相睇識0既，老婆同女住廣州，而家個女 7 歲大....」
Supervisor 趨前，神色頗凝重地問: 「咁...佢地行唔行到房 ?」
同學微頓，「得... 個女都 7 歲...」語帶少許猶豫，但很快便接上。
「你知喇，有兩個器官架嘛，你知佢用邊個...」Supervisor 追問那同學...
一眾動作靜止，連眼睛也沒轉，Supervisor 立時察覺有異。
「雙體式喎，你講話係雙體式.........哦..... 你話佢地係相睇果陣識。我以為你.....」
大家穴道突然被解開，陷入一陣爆笑.....
又是存在主義的技倆嗎 ?
這是五集中我最喜歡的一本。
「人類的恐懼與需求將會界定神靈的本質，一旦定型之後，他們就會忘記自己曾經身為這種型態。他們會開始狩獵人類、統治人類、接受人類的膜拜、摧毀人類的生命...」
「這個年代裏，所有天使都還沒有發展出個別特質，一直要等到他們跟人類互動超過數個世紀之後，才會慢慢顯露出獨特的性格。此時的他們比較像是兩台機器，接受主人的命令前來執行必要的工作。在我看來，光明與黑暗的天使在本氣質上似乎沒有多大的差異。」
人類在此書的角色身份未明，既非神祇又非靈物，暫只是物質界的指標，卻左右著「世界之外的世界」，隱隱暗含我的思想意志便是力量，便是意義。而且...系統觀的互相塑造模型不是隨處可見嗎 ?
「人類的恐懼與需求將會界定神靈的本質，一旦定型之後，他們就會忘記自己曾經身為這種型態。他們會開始狩獵人類、統治人類、接受人類的膜拜、摧毀人類的生命...」「這個年代裏，所有天使都還沒有發展出個別特質，一直要等到他們跟人類互動超過數個世紀之後，才會慢慢顯露出獨特的性格。此時的他們比較像是兩台機器，接受主人的命令前來執行必要的工作。在我看來，光明與黑暗的天使在本氣質上似乎沒有多大的差異。」
《錯過的旅途》賽門、葛林
人類在此書的角色身份未明，既非神祇又非靈物，暫只是物質界的指標，卻左右著「世界之外的世界」，隱隱暗含我的思想意志便是力量，便是意義。而且...系統觀的互相塑造模型不是隨處可見嗎 ?
這書精彩處當然不在時間迴圈的思考模式，而是書的「精神重量」踏破物質界的固硬地殼，帶我們進入深邃的概念與想像的遼闊領土，只是不能免於本質所限，絕對的自由卻並非理想樂土。
最後主角能否力挽狂瀾、肆意屑弄命運這惡棍，我們拭目以待吧!
ps: 個人認為梅林和妮暮的死非常無辜和兒戲! 可能我也是個坎莫洛特的浪漫主義者，還早早愛上梅林也不自知...
18.11.07
《第十三個故事》
讀了三分一。有點像《百年孤寂》的魔幻寫實、和《風之影》的悲劇感和戲中戲。閱多三分一。明天要去 Godiva 買可可粉，忙時也可泡杯熱可可，解壓忘憂。
完成整本書。感覺有點失望，虎頭蛇尾的結局，草草收場，讓死者出場是多餘，而且交代所有人物寵物去向並不代表圓滿喔。
16.11.07
黑澤ing (下)
黑澤明還是副導演時，他的恩師山本嘉次郎 (導演)一有時間就和副導演做一種遊戲。
「這種遊戲是設定一個主題，據此寫個短鏡頭劇本...
不過誰也沒有勝過山本先生，因為他的短鏡頭劇本非常有趣。
比如以 "熱"為題的短鏡頭劇本，山本先生是這樣寫的:
場景是賣牛肉雞素燒的二樓。
夏天炎炎的夕陽，灼燒著業已關閉的紙窗。窄小的房間裡，一個男人滿頭大汗，擦都不擦地向女招待求愛。
旁邊的雞素燒鍋咕嘟咕嘟地晌著。湯快要熬干了，滿屋子牛肉味兒。」
而黑澤明的版本是由自己上演的 :
「... 我幫著搭建外景的小木屋時，手套上沾著雪就去烤火，結果雙手濕透。到了傍晚，手已凍得失去知覺，全体人員只好逃回溫泉旅館。那時我想直奔澡塘跳進熱水裏，但那溫泉太熱下不去，我就想加入一些涼水。結果從水槽裏打上水來，一不小心在凍了冰的洗衣槽那兒滑倒，一桶水從頭淋到腳跟。
我一輩子人沒有感到過這麼冷。
這可能和前面提到過的山本先生表現 "熱"的短鏡頭劇本不相上下，大概堪稱表現"冷"的短鏡頭劇本。」
「這種遊戲是設定一個主題，據此寫個短鏡頭劇本...
不過誰也沒有勝過山本先生，因為他的短鏡頭劇本非常有趣。
比如以 "熱"為題的短鏡頭劇本，山本先生是這樣寫的:
場景是賣牛肉雞素燒的二樓。
夏天炎炎的夕陽，灼燒著業已關閉的紙窗。窄小的房間裡，一個男人滿頭大汗，擦都不擦地向女招待求愛。
旁邊的雞素燒鍋咕嘟咕嘟地晌著。湯快要熬干了，滿屋子牛肉味兒。」
而黑澤明的版本是由自己上演的 :
「... 我幫著搭建外景的小木屋時，手套上沾著雪就去烤火，結果雙手濕透。到了傍晚，手已凍得失去知覺，全体人員只好逃回溫泉旅館。那時我想直奔澡塘跳進熱水裏，但那溫泉太熱下不去，我就想加入一些涼水。結果從水槽裏打上水來，一不小心在凍了冰的洗衣槽那兒滑倒，一桶水從頭淋到腳跟。
我一輩子人沒有感到過這麼冷。
這可能和前面提到過的山本先生表現 "熱"的短鏡頭劇本不相上下，大概堪稱表現"冷"的短鏡頭劇本。」
《哈蟆的油》黑澤明
"冷"這表現差太多了。"熱"的表現不止於五感 : 視、聽、味、嗅、觸，空間感加上情慾的壓迫和張力，實在把"熱"發揮得淋漓盡致。
14.11.07
黑澤ing (中)
「唯一感到遺憾的是，由於自己閱歷尚淺，沒有很好地利用這難得一遇的神風。
我自以為充分地拍攝了強風中的鏡頭，到了剪輯的時候才發現，不僅談不到充分兩字，而且還有許多該拍而未拍下的，使人追悔莫及。
在嚴酷的條件下，一個小時會使人感到有兩三個小時那麼長。但那是嚴酷的條件使人產生的感覺。實際上一個小時的工作量就是一個小時的工作量，這一點並沒有變化。
所以，從此以後，在嚴酷的條件下，即使覺得已經很夠了，但我還是要堅持干下去，干它三倍的工作，這樣才勉強達到夠用的水平。
這就是我從《姿三四郎》強風中拍片學來的痛苦經驗。」
深具同感。回想昔日一拿起相機便忘記時間流逝，那種忘我的經驗動人回味之餘，實際上也是拍到好照片的要素。與拍攝的環境建立更深了解，需要時間去觀察不同角度光影組合，還需定下神來，清理雜念，重新調教自己的感覺。對我而言，攝影是快不了，因為需要思考。還記得在黃龍、九寨溝、4 姑娘山、北彊、仙台，一拍便拍它 3-5 小時 ; 那管是下雨或雪，微風或強風、晨曦或黃昏、有氣或沒氣、渾然忘我 。當年便害苦了我的同伴們，苦悶但耐心地等待我。
近年的我變了，怕冷又怕痛、嫌早又嫌重、不想辛苦又避免麻煩。這在香格里拉和西藏兩次旅行尤其顯著。記得在納木錯時，根本不想到室外去，那時大風刮雪，天地飄零，我在門邊窺探這異域，美極了! 但我太凍了，動不了一根指頭，結果連「勉強達到夠用的水平」的照片也拍不到。
剛到達拉薩看到布達拉宮時，完全不敢相信，不可能這麼小，它不是很宏偉的嗎 ? 還以為自己到了世界之窗! 那時才知道被騙了，除暗暗佩服別人的攝影技術了得，也讚嘆攝影視覺比例的高明和虛偽。在這特別「嚴酷」的條件下，我沒有堅持下去。而現在我也沒有勇氣告訴別人，照片中是西藏拉薩的布達拉宮，而非深圳的世界之窗。
以上非關閱歷深淺，也未至痛苦追悔。在嚴酷的條件下，才見真彰。
雪後納木錯的紅屁股羊兒
我自以為充分地拍攝了強風中的鏡頭，到了剪輯的時候才發現，不僅談不到充分兩字，而且還有許多該拍而未拍下的，使人追悔莫及。
在嚴酷的條件下，一個小時會使人感到有兩三個小時那麼長。但那是嚴酷的條件使人產生的感覺。實際上一個小時的工作量就是一個小時的工作量，這一點並沒有變化。
所以，從此以後，在嚴酷的條件下，即使覺得已經很夠了，但我還是要堅持干下去，干它三倍的工作，這樣才勉強達到夠用的水平。
這就是我從《姿三四郎》強風中拍片學來的痛苦經驗。」
《哈蟆的油》黑澤明
深具同感。回想昔日一拿起相機便忘記時間流逝，那種忘我的經驗動人回味之餘，實際上也是拍到好照片的要素。與拍攝的環境建立更深了解，需要時間去觀察不同角度光影組合，還需定下神來，清理雜念，重新調教自己的感覺。對我而言，攝影是快不了，因為需要思考。還記得在黃龍、九寨溝、4 姑娘山、北彊、仙台，一拍便拍它 3-5 小時 ; 那管是下雨或雪，微風或強風、晨曦或黃昏、有氣或沒氣、渾然忘我 。當年便害苦了我的同伴們，苦悶但耐心地等待我。
近年的我變了，怕冷又怕痛、嫌早又嫌重、不想辛苦又避免麻煩。這在香格里拉和西藏兩次旅行尤其顯著。記得在納木錯時，根本不想到室外去，那時大風刮雪，天地飄零，我在門邊窺探這異域，美極了! 但我太凍了，動不了一根指頭，結果連「勉強達到夠用的水平」的照片也拍不到。
剛到達拉薩看到布達拉宮時，完全不敢相信，不可能這麼小，它不是很宏偉的嗎 ? 還以為自己到了世界之窗! 那時才知道被騙了，除暗暗佩服別人的攝影技術了得，也讚嘆攝影視覺比例的高明和虛偽。在這特別「嚴酷」的條件下，我沒有堅持下去。而現在我也沒有勇氣告訴別人，照片中是西藏拉薩的布達拉宮，而非深圳的世界之窗。
以上非關閱歷深淺，也未至痛苦追悔。在嚴酷的條件下，才見真彰。
雪後納木錯的紅屁股羊兒
12.11.07
黑澤ing
「... 破罐子破摔地哼哼著唱起歌來的時候，攝制組的一人忽然揮手制止大家，他指著窗外讓大家看。
只見箱根外輪山遮住了一半的雲開始動了，蘆湖上空的雲翻騰奔涌，好像龍要升天一般。
一股涼風從窗外刮進來，把壁龕上的掛軸刮起，噹啷作晌。
大家無言地互相瞧了瞧便急忙站起，馬上展開了一場鑿戰。
從旅館到外景現場不算遠，只有兩公里之遙。
路上大家頂著強風，弓著腰，艱難地前進。
外景場地是個土崗，盡管荒草的尾花業已凋謝，但花穗仍隨風俯仰，就像台風下波濤洶湧的大海一樣。原野的上空，大風把濃雲撕成碎片，風卷雲番，轉瞬即逝 ...」
以上折錄自黑澤明的自傳《哈蟆的油》，記述攝制電影《姿三四郎》最后高潮 - 右京原決鬥的的經過。黑澤的寫作很有電影感，一個鏡頭接一個鏡頭般，看書如看電影，名乎其實的腦漿(Plasma) 映像，除演員樣貌顏色音樂形狀等因人而異，讀者依照(跟)劇本便可獨自上映。結果腦內滿滿是景象，畫面，情節，加上聲音，對白，配樂，不斷整合拍制。Client 的家事過程，兩三代進出離聚，你的喜怒哀樂，太后的嬉笑怒罵，兩個追住一個不放，燃燒中痛(苦)快(感) ，火浴激烈糾纏的靈魂，抬起他們拋在海吧，便風平浪靜了 !!!???!!!
多麼想舉手， 帶半分超然狂傲地說: 「family therapy is just my hobby. I have to work 2, dreaming day & night is my professional...」
山雨欲來風滿樓，坐在窗前，涼風溫柔撫摸面頰頸根，空氣柔滑無痕，伴隨吳奇隆的《煙火》，期望一陣風飛帶走「塵封的記憶，映在我的心底是無窮無盡的永久」。
登升仙鶴追逐神針，「愛他的真和狂傲」，仰止高山，笑看風雲。
只見箱根外輪山遮住了一半的雲開始動了，蘆湖上空的雲翻騰奔涌，好像龍要升天一般。
一股涼風從窗外刮進來，把壁龕上的掛軸刮起，噹啷作晌。
大家無言地互相瞧了瞧便急忙站起，馬上展開了一場鑿戰。
從旅館到外景現場不算遠，只有兩公里之遙。
路上大家頂著強風，弓著腰，艱難地前進。
外景場地是個土崗，盡管荒草的尾花業已凋謝，但花穗仍隨風俯仰，就像台風下波濤洶湧的大海一樣。原野的上空，大風把濃雲撕成碎片，風卷雲番，轉瞬即逝 ...」
以上折錄自黑澤明的自傳《哈蟆的油》，記述攝制電影《姿三四郎》最后高潮 - 右京原決鬥的的經過。黑澤的寫作很有電影感，一個鏡頭接一個鏡頭般，看書如看電影，名乎其實的腦漿(Plasma) 映像，除演員樣貌顏色音樂形狀等因人而異，讀者依照(跟)劇本便可獨自上映。結果腦內滿滿是景象，畫面，情節，加上聲音，對白，配樂，不斷整合拍制。Client 的家事過程，兩三代進出離聚，你的喜怒哀樂，太后的嬉笑怒罵，兩個追住一個不放，燃燒中痛(苦)快(感) ，火浴激烈糾纏的靈魂，抬起他們拋在海吧，便風平浪靜了 !!!???!!!
多麼想舉手， 帶半分超然狂傲地說: 「family therapy is just my hobby. I have to work 2, dreaming day & night is my professional...」
山雨欲來風滿樓，坐在窗前，涼風溫柔撫摸面頰頸根，空氣柔滑無痕，伴隨吳奇隆的《煙火》，期望一陣風飛帶走「塵封的記憶，映在我的心底是無窮無盡的永久」。
登升仙鶴追逐神針，「愛他的真和狂傲」，仰止高山，笑看風雲。
23.10.07
21.10.07
「我已爬回家了，勿念」
今早起來，發現一短訊，於昨夜零晨 2:18 分發出，陌生人的電話號碼，內容是:
「我已爬回家了，勿念」!
於這段媽媽回鄉探親期間，獨個在家的我，第一個念頭是:「媽媽嗎? 已爬回家? 不是嘛...」
連忙起床出廳，看見一把掃把。喔 ! 母親真的回來了嗎 ? 又出去了嗎 ? 但門由內鎖上，她沒可能進來的，而且她不是明天才回來嗎 ?
「她為何發短訊 ? 連用手提也有困難，她怎懂得發短訊 ? 表哥幫她的嗎 ?」
再看看手機內短訊 ....
「爬回家? 為什麼用爬? 什麼才會用爬的? ....」
Oh come on... 最近十月 now 滿是奇情幻海驚慄恐怖電影，而我... 更看了不少....
放學返家，沒見媽媽。禁不住回了短訊 ...
「你如何午夜爬回家 ? 你又是誰 ?」
「我已爬回家了，勿念」!
於這段媽媽回鄉探親期間，獨個在家的我，第一個念頭是:「媽媽嗎? 已爬回家? 不是嘛...」
連忙起床出廳，看見一把掃把。喔 ! 母親真的回來了嗎 ? 又出去了嗎 ? 但門由內鎖上，她沒可能進來的，而且她不是明天才回來嗎 ?
「她為何發短訊 ? 連用手提也有困難，她怎懂得發短訊 ? 表哥幫她的嗎 ?」
再看看手機內短訊 ....
「爬回家? 為什麼用爬? 什麼才會用爬的? ....」
Oh come on... 最近十月 now 滿是奇情幻海驚慄恐怖電影，而我... 更看了不少....
放學返家，沒見媽媽。禁不住回了短訊 ...
「你如何午夜爬回家 ? 你又是誰 ?」
20.10.07
12 Disciples
- Simon: called Peter (Grk. petros, petra; Aram. kēf; Engl. rock) by Jesus, also known as Simon bar Jonah and Simon bar Jochanan (Aram.) and earlier (Pauline Epistles were written first) Cephas (Aram.) by Paul of Tarsus and Simon Peter, a fisherman from Bethsaida "of Galilee" (John 1:44; cf. 12:21)
- Andrew: brother of Peter, a Bethsaida fisherman and disciple of John the Baptist, and also the First-Called Apostle
- James and
- John: sons of Zebedee, called by Jesus Boanerges (an Aramaic name explained in Mk 3:17 as "Sons of Thunder")
- Philip: from Bethsaida "of Galilee" (John 1:44, 12:21)
- Bartholomew: in Aramaic "bar-Talemai?", "son of Talemai" or from Ptolemais, sometimes identified with the Nathanael of John 1:45-1:51.
- Thomas: also known as Judas Thomas Didymus - Aramaic T'oma' = twin, and Greek Didymous = twin
- James, son of Alphaeus: commonly identified with James the Less. Sometimes also identified with James the Just[2]
- Matthew: the tax collector, some identify with Levi son of Alphaeus
- Simon the Canaanite: called in Luke and Acts "Simon the Zealot", some identify with Simeon of Jerusalem, which others dispute on the grounds that Simeon was described at the time of Jesus' birth some thirty years before, as an old man not far from death. [3]
- Judas Iscariot: the name Iscariot may refer to the Judaean towns of Kerioth or to the sicarii (Jewish nationalist insurrectionists), or to Issachar. Also referred to (e.g. at John 6:71 and 13:26) as "Judas, the son of Simon". He was replaced as an apostle in Acts by Matthias.
- The identity of the other apostle of the twelve, traditionally called St. Jude, varies between the Synoptic Gospels and also between ancient manuscripts of each gospel: Mark names him as Thaddaeus; Different manuscripts of Matthew identify him as either Thaddeus or Lebbaeus (some later Latin manuscripts name him "Judas the Zealot", but this is regarded as an unlikely reading); Luke names him as Judas, son of James (translated in the KJV as: "Judas the brother of James" Luke 6:16).
18.10.07
11.10.07
文品指数
utop，您的评测结果：
语言的智慧来源于生活的积累与敏锐的思维；幽默开心之余，也能带来一些思索，此为难得。文章内容丰富，观点翔实可圈可点；架构清晰，逻辑性强，情节缜密， 可读性强；在用词范围方面可以着重下功夫改进。特点为信息量充足，因此可以多考虑创作偏重评论类的作品；同时，游记等介绍性质的题材也可以多多尝试。
- 21%
- 这个区间是比较正常的，看来你已经有了掌握神韵的感觉喔。
- 19%
- 这个区间是比较正常的，看来你已经有了掌握神韵的感觉喔。
- 17%
- 这个区间是比较正常的，看来你已经有了掌握神韵的感觉喔。
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